期刊
JOURNAL OF NATURAL PRODUCTS
卷 73, 期 8, 页码 1441-1443出版社
AMER CHEMICAL SOC
DOI: 10.1021/np100299v
关键词
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资金
- NIH [GM68944, R01GM0758556]
- American Foundation for Pharmaceutical Education (AFPE)
Eucapsitrione (1), an anthraquinone derivative with an indeno-anthracene-trione skeleton, was isolated from the cyanobacterium Eucapsis sp. (UTEX 1519) by bioassay-guided fractionation. The chemical structure was determined by analyzing MS and ID and 2D NMR spectroscopic data. Eucapsitrione (1) showed anti-Mycobacterium tuberculosis activity in the microplate Alamar blue assay and low-oxygen-recovery assay with MIC values of 3.1 and 6.4 mu M, respectively.
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