期刊
JOURNAL OF NATURAL PRODUCTS
卷 73, 期 12, 页码 2061-2063出版社
AMER CHEMICAL SOC
DOI: 10.1021/np1005289
关键词
-
资金
- Korean Government (MOEHRD) [KRF-2008-314-F00048]
- Brain Korea 21 graduate fellowship [09B2519]
The addition of CaBr2 to the fermentation of a marine-derived Fusarium tricinctum resulted in production of halogenated chlamydosporol analogues. Two new antimicrobial halogenated pyranopyranones, bromomethylchlamydosporols A (1) and B (2), and two known compounds, chlamydosporol (an inseparable epimeric mixture of 7R:7S = 1:1 from H-1 NMR data) (3) and fusarielin A (4), were isolated from the culture. The structures of 1 and 2 were assigned through a combination of spectroscopic data analyses. Compounds 1-4 exhibited mild antibacterial activity against Staphylococcus aureus, methicillin-resistant S. aureus, and multidrug-resistant S. aureus. The MIC values of each strain were as follows: compounds 1 and 2 showed an MIC of 15.6 mu g/mL against S. aureus, methicillin-resistant S. aureus, and multidrug-resistant S. aureus, and compounds 3 and 4 exhibited an MIC of 31.5 mu g/mL against S. aureus and methicillin-resistant S. aureus and 62.5 mu g/mL against multidrug-resistant S. aureus.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据