期刊
JOURNAL OF NATURAL PRODUCTS
卷 73, 期 11, 页码 1785-1791出版社
AMER CHEMICAL SOC
DOI: 10.1021/np100401f
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资金
- National Science Council of Taiwan [NSC-98-2113-M-110-002-MY3]
- Ministry of Education of Taiwan [98C031702]
Eight new eunicellin-base diterpenoids, hirsutalins A-H (1-8), were isolated from the soft coral Cladiella hirsuta. Their structures were elucidated by spectroscopic methods, particularly in 1D and 2D NMR experiments. The absolute configuration of 1 was determined by Mosher's method. Compounds 1, 5, and 6 have been shown to exhibit cytotoxicity toward several cancer cell lines. Compounds 2-4 and 8 were found to display significant in vitro anti-inflammatory activity in LPS-stimulated RAW264.7 macrophage cells by inhibiting the expression of the iNOS protein, with compound 2 also effectively reducing the level of COX-2 protein.
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