期刊
JOURNAL OF NATURAL PRODUCTS
卷 72, 期 2, 页码 284-289出版社
AMER CHEMICAL SOC
DOI: 10.1021/np8004858
关键词
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资金
- National High-Tech Research and Development Project [2006AA-09Z423]
- National Natural Science Foundation of China [20502035]
Four new asterosaponins, novaeguinosides A (1), B (2), C (3), and D (4), were isolated from the bioactive fraction of the starfish Culcita novaeguineae, as active compounds capable of promoting polymerization of tubulin. Their structures were elucidated by extensive spectroscopic studies and chemical evidence. Compounds I and 3 are characterized by sulfated side chains not previously found in asterosaponins, and 1 is the first example of a trisulfated asterosaponin. In the side chains of 2 and 4, the 26-carboxylic acid function is found as an amide derivative of taurine, which is a rare feature and first encountered among asterosaponins. All the asterosaponins showed cytotoxicity against two human tumor cell lines.
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