期刊
JOURNAL OF NATURAL PRODUCTS
卷 72, 期 8, 页码 1524-1528出版社
AMER CHEMICAL SOC
DOI: 10.1021/np900177m
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资金
- Natural Products Branch Repository Program at the National Cancer Institute
- NCI Open Repository, D. Sanglard (institute of Microbiology, University Hospital, Lausanne, Switzerland)
Bioassay-guided fractionation of the extract of Topsentia sp. led to the identification of two new sulfated sterols, geodisterol-3-O-sulfite (1) and 29-demethylgeodisterol-3-O-sulfite (2), the active constituents reversing efflux pump-mediated fluconazole resistance. Both compounds enhanced the activity of fluconazole in a Saccharomyces cerevisiae strain overexpressing the Candida albicans efflux pump MDR1, as well as in a fluconazole-resistant Candida albicans clinical isolate known to overexpress MDR1. These results provide insight into the clinical utility of combining efflux pump inhibitors with current antifungals to combat the resistance associated with opportunistic fungal infections caused by C. albicans.
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