期刊
JOURNAL OF NATURAL PRODUCTS
卷 72, 期 9, 页码 1669-1672出版社
AMER CHEMICAL SOC
DOI: 10.1021/np9003799
关键词
-
资金
- National Natural Science Foundation [30630072, 30721005]
Four new alkaloids, 17-hydroxydaphnigraciline (1), subdaphnidine A (2), daphnezomine L methyl ester (3), and 11-hydroxycodaphniphylline (4), along with 24 known analogues, were isolated from the leaves of Daphniphyllum subverticillatum. The structures of 1-4 were elucidated on the basis of spectroscopic methods and from chemical evidence. Daphnilongeridine (5) showed cytotoxicity against several tumor cell lines at IC50 values in the range 2.4-9.7 mu M and against the HMEC human microvascular endothelial cell line with an IC50 of 2.7 mu M.
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