期刊
JOURNAL OF NATURAL PRODUCTS
卷 72, 期 11, 页码 2049-2052出版社
AMER CHEMICAL SOC
DOI: 10.1021/np9003883
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资金
- Thailand Research Fund [DBG5180014]
- Center for Environmental Health, Toxicology and Management of Chemicals (ETM)
- NSF-REU [INT-0123857]
- Direct For Mathematical & Physical Scien [0850693] Funding Source: National Science Foundation
- Division Of Chemistry [0850693] Funding Source: National Science Foundation
A new tyrosine-derived metabolite, aspergillusol A (4), was isolated on a grain scale, together with a methyl ester of 4-hydroxyphenylpyruvic acid oxime (5) and secalonic acid A, from the marine-derived fungus Aspergillus aculeatus CR1323-04. The tetraol in 4 was identified as erythritol by comparison of the H-1 NMR spectrum of its benzoylated derivative with those of benzoylated erythritol (7) and D-threitol (8), as well as by cellulose-based chiral HPLC analysis. Aspergillusol A (4) selectively inhibited alpha-glucosidase from the yeast Saccharomyces cerevisiae, but it was inactive toward the a.-glucosidase from the bacterium Bacillus stearothermophilus.
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