期刊
JOURNAL OF NATURAL PRODUCTS
卷 72, 期 3, 页码 469-472出版社
AMER CHEMICAL SOC
DOI: 10.1021/np800598t
关键词
-
资金
- NIH [GM067725, AI47818]
Nature has evolved finely tuned strategies to synthesize rare and complex natural products such as the enterocin family of polyketides from the marine bacterium Streptomyces maritimus. Herein we report the directed ex vivo multienzyme syntheses of 24 unnatural 5-deoxyenterocin and wailupemycin F and G analogues, 18 of which are new. We have generated molecular diversity by priming the enterocin biosynthesis enzymes with unnatural substrates and have illustrated further the uniqueness of this type 11 polyketide synthase by way of exploiting its unusual starter unit biosynthesis pathways.
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