期刊
JOURNAL OF NATURAL PRODUCTS
卷 72, 期 4, 页码 608-612出版社
AMER CHEMICAL SOC
DOI: 10.1021/np800377y
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资金
- Conselho Nacional de Desenvolvimento Cientifico (CNPq) (Brazil)
The analgesic potential of six 14-membered-ring cyclopeptide alkaloids, namely, franganine (1), discarine B (2), scutianines B (3), C (4), and D (5), and adouetine X (6), have been investigated. Among the compounds tested, only franganine (1) and adouetine X (6) produced antinociceptive effects in a mouse model of acute pain, without inducing undesirable side effects. Furthermore, compound 6 also exhibited a pronounced analgesic effect in a chronic neuropathic pain model in mice. It has been found that adouetine X (6) can decrease the activities of Ca2+-ATPase and Na+/K+-ATPase in vitro. Thus, the present findings have demonstrated that adouetine X (6) is a promising analgesic agent.
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