期刊
JOURNAL OF NATURAL PRODUCTS
卷 71, 期 12, 页码 1977-1982出版社
AMER CHEMICAL SOC
DOI: 10.1021/np800544b
关键词
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资金
- Canada Research Chair Program NSERC
- University of Prince Edward Island
- Canada Foundation for Innovation
- Atlantic Innovation Fund
- Jeanne and Jean-Louis Levesque Foundation
Novel lipidyl pseudopteranoids, lipidyl pseudopteranes A-F (1-6), have been isolated from the soft coral Pseudopterogorgia acerosa collected from the Bahamas. Structure elucidation of the six new compounds was based on 1D and 2D NMR data and mass spectrometry, and a biomimetic synthesis of 1 from pseudopterolide (7) was used to help establish its absolute configuration. These structures represent the first report of a pseudopterane diterpene with a fatty acid moiety. Lipidyl pseudopteranes A and D exhibited modest yet selective inhibitory activity against protein tyrosine phosphatase 1B, a promising drug target.
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