期刊
JOURNAL OF NATURAL PRODUCTS
卷 71, 期 7, 页码 1121-1126出版社
AMER CHEMICAL SOC
DOI: 10.1021/np070110k
关键词
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Nine tetraprenyltoluquinol-related metabolites (1-9) have been isolated from the organic extract of the temperate brown alga Halidrys siliquosa that exhibits antifouling properties. The planar structure of compounds 1-9 was elucidated on the basis of extensive spectroscopic analysis and by comparison of the data with those of related metabolites. Antifouling and toxicity tests were conducted on these compounds: the most active (compounds 2, 6, and 9) inhibited both the growth of four strains of bacteria (MICs < 2.5 mu g/mL) and settlement of cyprids of Balanus amphitrite (EC50 < 5 mu g/mL), the latter at nontoxic concentrations (LC50 > 5 mu g/mL).
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