期刊
JOURNAL OF NATURAL PRODUCTS
卷 71, 期 9, 页码 1643-1646出版社
AMER CHEMICAL SOC
DOI: 10.1021/np8003003
关键词
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资金
- State Basic Research Project [2004CB719601]
- National Hi-Tech Research and Development Project [2007AA021506]
- Key Project of Chinese Academy of Sciences [KSCX2-YW-G013]
- National Natural Science Foundation of China [30670055]
Five new asterric acid derivatives, ethyl asterrate (3), n-butyl asterrate (4), and geomycins A-C (6-8), have been isolated from Cultures of an isolate of the Antarctic ascomycete fungus Geomyces sp. The structures of these metabolites were elucidated by NMR spectroscopy. The absolute configuration of 8 was determined by application of the CD excitation chirality method. Compound 7 displayed antifungal activity against Aspergillus fumigatus, whereas 8 showed antimicrobial activities against Gram-positive and Gram-negative bacteria.
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