Lanostane-type triterpenoids from the roots of Kadsura coccinea

Seven new lanostane-type triterpenoids, seco-coccinic acids A-F (1-6) and coccinilactone A (7), were isolated from the roots of Kadsura coccinea. Their structures were established on the basis of spectroscopic data analysis. The absolute configuration at C-24 of compound 5 was confirmed by the modified Mosher's method. The cell growth inhibitory effects of these compounds were determined in human leukemia HL-60 cells, and it was found that compounds 1, 2, 3, and 5 exhibited antiproliferative effects with GI(50) values ranging from 6.8 to 42.1 mu M.