期刊
JOURNAL OF NATURAL PRODUCTS
卷 71, 期 10, 页码 1686-1691出版社
AMER CHEMICAL SOC
DOI: 10.1021/np800266a
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资金
- Instituto Mexicano del Seguro Social [FOFOI 2005/1/I/021]
- CONACyT [186764]
Four new partially acylated tetrasaccharides of 11-hydroxyhexadecanoic acid (1-4) were isolated from a methanolic extract of Ipomoea tyrianthina. The structures of these compounds were elucidated by spectroscopic and chemical methods. The resin glycoside composition of I.tyrianthina varied with the location of growth in Mexico. Compounds 1-4 showed anti mycobacterial activity, were cytotoxic against the KB cell line, and, in a mouse model. exhibited potentiation of hypnosis induced by pentobarbital, protected against seizures induced by pentylenetetrazole, and released GABA and glutamic acid.
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