期刊
JOURNAL OF NATURAL PRODUCTS
卷 71, 期 3, 页码 473-477出版社
AMER CHEMICAL SOC
DOI: 10.1021/np070603p
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资金
- Intramural NIH HHS Funding Source: Medline
A new highly unsaturated macrolide lactam, termed mirabilin (1), was isolated from the aqueous extract of the marine sponge Siliquariaspongia mirabilis. Mirabilin is characterized by the presence of a 35-membered macrolide lactam ring bearing a pentadiene conjugated system and a tetrasubstituted tetrahydropyran ring. A linear polyketide moiety is attached to the macrocyclic ring through an amide linkage. The structure of mirabilin was determined using extensive 2D NMR and ESIMS and tandem MS techniques. Mirabilin inhibits the growth of the tumor cell line HCT-116 with an IC50 value of 0.27 +/- 0.09 mu M and is noncytotoxic to several other cell lines.
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