期刊
JOURNAL OF NATURAL PRODUCTS
卷 71, 期 11, 页码 1877-1880出版社
AMER CHEMICAL SOC
DOI: 10.1021/np8003886
关键词
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资金
- National Natural Science Foundation [30672523, 90713037]
- Ministry of Education [706030, 20050316008]
- New Century Excellent Talents in University [NCET-05-0495]
Bredemolic acid (3) is a naturally occurring 2 beta,3 alpha-isomer of maslinic acid (1) that is an allosteric site inhibitor of glycogen phosphorylase (GP). A practical synthesis of 3 was accomplished (18% yield) in five steps starting from the readily available 2 beta,3 beta-diol 6a. In a similar fashion, 2 beta,3 alpha-dihydroxyurs-12-en-28-oic acid (4) was synthesized as a natural 2 beta,3 alpha-isomer of corosolic acid (2). Compounds 3 and 4 exhibited significant inhibitory activity against rabbit muscle GPa with IC50 values of 6.25 and 1.1 mu M, respectively.
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