期刊
JOURNAL OF NATURAL PRODUCTS
卷 71, 期 11, 页码 1927-1929出版社
AMER CHEMICAL SOC
DOI: 10.1021/np8005259
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资金
- NIH [CA24487, R01 GM023928-25]
- NSF
- Natural Products Branch of the National Cancer Institute [NPID N102479]
Bioassay-guided fractionation of Physocarpus capitatus yielded two new cucurbitacins (3 and 4) along with the known cucurbitacin F (1) and dihydrocucurbitacin F (2). Preliminary mechanism of action studies indicate that the cucurbitacins cause actin aggregates and inhibit cell division.
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