期刊
JOURNAL OF NATURAL PRODUCTS
卷 71, 期 7, 页码 1297-1300出版社
AMER CHEMICAL SOC
DOI: 10.1021/np800150m
关键词
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A new chlorinated cyclic pentapeptide, hydroxycyclochlorotine (1), has been isolated from Penicillium islandicum, and the structure including absolute stereochemistry of 1 and conformational properties of 1 and cyclochlorotine (2) in DMSO-d(6) were elucidated by using extensive 2D NMR and chemical means. Hydroxycyclochlorotine (1) and astin B (3) from Aster tataricus, each containing an allo threonine at residue 2, have a cis proline configuration, whereas cyclochlorotime (2) has two conformational states in solution, which may be produced from cis-trans isomerization of the proline amide bond. The presence of an intramolecular hydrogen bond between Ser(3)-NH and a hydroxyl oxygen atom of alloThr(2) may serve to maintain the backbone conformation with a cis proline amide bond.
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