期刊
JOURNAL OF NATURAL MEDICINES
卷 67, 期 4, 页码 838-843出版社
SPRINGER JAPAN KK
DOI: 10.1007/s11418-012-0739-7
关键词
LC-MS; Aristolochic acid; Crude drug; Solid-phase extraction
资金
- Ministry of Education, Culture, Sports, Science and Technology
- Grants-in-Aid for Scientific Research [24590838] Funding Source: KAKEN
The official Japanese method for analyzing aristolochic acid I (AA-I) in Asiasarum root using conventional high-performance liquid chromatography (HPLC) is described in the Japanese Pharmacopoeia, Sixteenth Edition. Interfering peaks of AA-I sometimes appear after HPLC analysis of crude drugs. A selective analytical method is needed to determine definitively whether AA-I is present in crude drugs. In this study, we developed a selective method that combined solid-phase extraction and liquid chromatography/mass spectrometry (LC/MS) which may be useful for identifying AA-I in crude drugs and for quality control.
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