期刊
JOURNAL OF NATURAL MEDICINES
卷 66, 期 1, 页码 166-176出版社
SPRINGER JAPAN KK
DOI: 10.1007/s11418-011-0568-0
关键词
Curcumin-like diarylpentanoids; Anti-melanogenesis; Tyrosinase activity; Tyrosinase expression; Melanin degradation
资金
- Ministry of Education, Culture, Sports, Science, and Technology of Japan
- Open Research Center in Hoshi University
- Ministry of Science Technology and Innovation under the SAGA
Anti-melanogenesis screening of 47 synthesized curcumin-like diarylpentanoid analogues was performed to show that some had a potent inhibitory effect on the melanogenesis in B16 melanoma cells. Their actions were considered to be mostly due to tyrosinase inhibition, tyrosinase expression inhibition, and melanin pigment degradation. The structure-activity relationships of those curcumin-like diarylpentanoid analogues which inhibited the melanogenesis and tyrosinase activity were also discussed. Of those compounds assayed, (2E,6E)-2,6-bis(2,5-dimethoxybenzylidene)cyclohexanone showed the most potent anti-melanogenesis effect, the mechanism of which is considered to be the degradation of the melanin pigment in B16 melanoma cells, affecting neither the tyrosinase activity nor tyrosinase expression.
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