期刊
JOURNAL OF NATURAL MEDICINES
卷 64, 期 3, 页码 252-256出版社
SPRINGER JAPAN KK
DOI: 10.1007/s11418-010-0400-2
关键词
Psidium guajava L.; Benzophenone galloyl glycoside; Flavonol galloyl glycoside
资金
- Ministry of Health and Welfare of Japan [19980070]
- Ministry of Education, Science, Sports and Culture of Japan to Nihon University
- MEXT (Ministry of Education, Culture, Sports, Science and Technology) of Japan [2002-2007, 2007-2010]
New benzophenone and flavonol galloyl glycosides were isolated from an 80% MeOH extract of Psidium guajava L. (Myrtaceae) together with five known quercetin glycosides. The structures of the novel glycosides were elucidated to be 2,4,6-trihydroxybenzophenone 4-O-(6aEuro(3)-O-galloyl)-beta-d-glucopyranoside (1, guavinoside A), 2,4,6-trihydroxy-3,5-dimethylbenzophenone 4-O-(6aEuro(3)-O-galloyl)-beta-d-glucopyranoside (2, guavinoside B), and quercetin 3-O-(5aEuro(3)-O-galloyl)-alpha-l-arabinofuranoside (3, guavinoside C) by NMR, MS, UV, and IR spectroscopies. Isolated phenolic glycosides showed significant inhibitory activities against histamine release from rat peritoneal mast cells, and nitric oxide production from a murine macrophage-like cell line, RAW 264.7.
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