期刊
JOURNAL OF NATURAL MEDICINES
卷 65, 期 1, 页码 237-240出版社
SPRINGER JAPAN KK
DOI: 10.1007/s11418-010-0476-8
关键词
Oleoside-type secoiridoid glucoside; Aglycone; Enzymatic hydrolysis; Cytotoxic activity; EGFR tyrosine kinase inhibitory activity
资金
- Ministry of Education, Culture, Sports, Science and Technology, Japan
- Grants-in-Aid for Scientific Research [23501310] Funding Source: KAKEN
Hydrolysis of oleoside-type secoiridoid glucosides, oleuropein (1) and ligustroside (2), in the presence of beta-glucosidase provided their aglycones, named (5S,8R,9S)-7-3,4-dihydroxyphenethyl elenolate (3) and (5S,8R,9S)-7-4-hydroxyphenethyl elenolate (4), respectively. The structures of 3 and 4 were identified by spectroscopic means and optical rotation measurements. Evaluation of the cytotoxic and epidermal growth factor receptor (EGFR) tyrosine kinase inhibitory activities of compounds 1-4 showed that compounds 3 and 4 exhibited moderate cytotoxicity against a disease-oriented panel of 39 human cancer cell lines in vitro, whereas compound 3 inhibited the enzyme.
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