期刊
JOURNAL OF NATURAL MEDICINES
卷 65, 期 2, 页码 370-374出版社
SPRINGER JAPAN KK
DOI: 10.1007/s11418-010-0485-7
关键词
Cnidium monnieri; Coumarin; HSC-T6; Hepatic stellate cells; Osthol; Imperatorin
资金
- Medical Research Center [2010-0029480]
- Regional Core Research Program (Chungbuk BIT Research-Oriented University Consortium)
- National Research Foundation of Korea (NRF) [2010-0025054]
- National Research Foundation of Korea [2010-0025054] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The CHCl3 fraction of Cnidium monnieri fruits significantly inhibited the proliferation of hepatic stellate cells in an in-vitro assay system employing HSC-T6 hepatic stellate cell lines. Activity-guided fractionation of the CHCl3 fraction of C. monnieri led to the isolation of ten coumarins: osthol (1), meranzin (2), auraptenol (3), meranzin hydrate (4), 7-hydroxy-8-methoxy coumarin (5), imperatorin (6), xanthotoxol (7), xanthotoxin (8), bergapten (9) and isopimpinellin (10). Of these, compounds 1 and 6 significantly inhibited proliferation of HSCs in a time- and concentration-dependent manner. In addition, compounds 1 and 6 significantly reduced collagen content in HSC-T6 cells.
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