期刊
JOURNAL OF NATURAL MEDICINES
卷 62, 期 2, 页码 174-178出版社
SPRINGER JAPAN KK
DOI: 10.1007/s11418-007-0223-y
关键词
Helichrysum maracandicum; isosalipurposide; anticarcinogenic activity; naringenin chalcone; two-stage carcinogenesis
An ethanol extract of Helichrysum maracandicum showed antiproliferative activity against cultured cells of SENCAR mouse in an in vitro assay, and activity-guided fractionation of the extract resulted in the isolation of isosalipurposide as an active substance. Naringenin chalcone, the aglycone of isosalipurposide, also showed strong antiproliferative activity. An in vivo assay of two-stage carcinogenesis on mouse skin revealed that epidermal application of isosalipurposide resulted in delayed formation of papillomas. Western blot analysis showed that the expression of p38 mitogen-activated protein kinase was suppressed by the administration of naringenin chalcone or isosalipurposide, which might be related to the anticarcinogenic activity.
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