期刊
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
卷 14, 期 1, 页码 71-97出版社
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jnn.2014.9112
关键词
Atomic Force Microscopy (AFM); Raman Spectroscopy; Raman Endoscopy; Medical Science; Diagnosis; Pharmacotherapy; Medical Device Therapy; Nanostructure; Biomechanical Property; Physicochemical Property
类别
资金
- Korean Health Technology R&D Project, Ministry of Health and Welfare, Republic of Korea [A110216]
- Korea Health Promotion Institute [A110216] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
This paper reviews the recent research and application of atomic force microscopy (AFM) and Raman spectroscopy techniques, which are considered the multi-functional and powerful toolkits for probing the nanostructural, biomechanical and physicochemical properties of biomedical samples in medical science. We introduce briefly the basic principles of AFM and Raman spectroscopy, followed by diagnostic assessments of some selected diseases in biomedical applications using them, including mitochondria isolated from normal and ischemic hearts, hair fibers, individual cells, and human cortical bone. Finally, AFM and Raman spectroscopy applications to investigate the effects of pharmacotherapy, surgery, and medical device therapy in various medicines from cells to soft and hard tissues are discussed, including pharmacotherapy-paclitaxel on Ishikawa and HeLa cells, telmisartan on angiotensin II, mitomycin C on strabismus surgery and eye whitening surgery, and fluoride on primary teeth-and medical device therapy-collagen cross-linking treatment for the management of progressive keratoconus, radiofrequency treatment for skin rejuvenation, physical extracorporeal shockwave therapy for healing of Achilles tendinitis, orthodontic treatment, and tooth-brushing time to minimize the loss of teeth after exposure to acidic drinks.
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