期刊
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
卷 14, 期 1, 页码 983-989出版社
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jnn.2014.9190
关键词
pH-Sensitive; Ketal Polymers; Polyketal; Preparation and Characterization; Drug Delivery
类别
资金
- National Basic Research Program of China (973 Plan) [2012CB724003]
- National Science Foundation of China (NSFC) [81302718]
- Taishan Scholar Project
- State Key Laboratory of Long-acting and Targeting Drug Delivery System [YX12H071]
- A Technology Development Program Projects of Shandong Province [2011YD18075]
This article reviews the recent developments on novel pH-sensitive ketal-based biodegradable polymeric drug delivery systems. Due to the degradation of ketal derivatives, neutral alcohols and ketones, ketal derivatives can be used to fabricate pH-degradable polymer with pH-degradable ketal linkages in new drug delivery systems by avoiding inflammatory problems. Due to the novelty of ketal polymers, there were few reports about ketal polymers. The review starts with a brief introduction to the pH-sensitive drug delivery system, followed by the structure, preparation and characterization techniques of ketal polymers. Thereafter, the promising applications in various diseases in relation to micro/nano drug carriers based on ketal polymers are summarized and discussed.
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