期刊
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
卷 130, 期 -, 页码 9-14出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbb.2014.12.009
关键词
Agmatine; Depression; Antidepressants; NMDA
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [307687/2009-0]
- Coordenacao de Aperfeicoamento de Pessoal de Ensino Superior (CAPES)
- Rede Instituto Brasileiro de Neurociencias (IBN-Net/CNPq) [01.06.0842-00]
- NENASC Project (PRONEX-FAPESC/CNPq) [1262/2012-9]
Agmatine, an endogenous guanidine amine, has been shown to produce antidepressant-like effects in animal studies. This study investigated the effects of the combined administration of agmatine with either conventional monoaminergic antidepressants or the N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 in the tail suspension test (TST) in mice. The aim was to evaluate the extent of the antidepressant synergism by examining the ability of a fixed dose of agmatine to shift the antidepressant potency of fluoxetine, imipramine, bupropion and MK-801. A sub-effective dose of agmatine (0.0001 mg/kg, p.o.) significantly increased the potency by which fluoxetine, imipramine, bupropion and MK-801 decreased immobility time in the TST by 2-fold (fluoxetine), 10-fold (imipramine and bupropion) and 100-fold (MK-801). Combined with previous evidence indicating a role of monoaminergic systems in the effect of agmatine, the current data suggest that agmatine may modulate monoaminergic neurotransmission and augment the activity of conventional antidepressants. Moreover, this study found that agmatine substantially augmented the antidepressant-like effect of MK-801, reinforcing the notion that this compound modulates NMDA receptor activation. These predinical data may stimulate future clinical studies testing the effects of augmentation therapy with agmatine for the management of depressive disorders. (C) 2014 Elsevier Inc All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据