期刊
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
卷 11, 期 8, 页码 6868-6874出版社
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jnn.2011.4251
关键词
Calcium Carbonate; XRD; SEM; Cytotoxicity
类别
资金
- NASA [NNX08BA47A, NCC-1-02038, NIH-1P20MD001822-1]
- NASA NSTI
- NSF- CREST
- Direct For Education and Human Resources
- Division Of Human Resource Development [1036494] Funding Source: National Science Foundation
- NASA [90797, NNX08BA47A] Funding Source: Federal RePORTER
The synthesis of nanoparticles and their functionalization to effectively utilize them in biological applications including drug delivery is currently a challenge. Calcium carbonate among many other inorganic nanosized particles offers promising results for such applications. We have synthesized calcium carbonate nanoparticles using polymer mediated growth technique, where one of the ions bound within polymer matrix and the other diffuses and reacts to form desired compound. The synthesized nanoparticles are characterized using X-ray diffraction, Scanning Electron Microscopy and spectroscopic techniques such as Fourier-Transform Infra-red spectroscopy and UV-Vis spectroscopy. The diameter of the calcium carbonate nanoparticles is estimated to be 39.8 nm and their biocompatibility studies showed no significant induction of oxidative stress or cell death even. at higher concentrations (50 mu g) upon exposure to He La and LE cells. Here, we report that the synthesized calcium carbonate nanosized particles using polymer mediated growth technique are biocompatible and can be safely used for biomedical applications.
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