期刊
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
卷 128, 期 -, 页码 41-49出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbb.2014.11.003
关键词
Spinosin; Elevated plus maze; Light/dark box; Open field test; GABA(A) receptor antagonist; 5-HT1A receptor antagonist
资金
- Ministry of Science and Technology [2012ZX09102201-018]
- National Science Foundation of China [30800301, 31170992, 31371038]
- Zhejiang Key Technology Innovation Team [2012R10044-08]
The present study investigated the anxiolytic-like effects of spinosin, one of the major flavonoids in Ziziphi Spinosae Semen (ZSS), in experimental models of anxiety compared with a known anxiolytic, diazepam. Repeated treatment with spinosin (2.5 and 5 mg/kg/day, p.o.) significantly increased the percentage of entries into and time spent on the open arms of the elevated plus maze compared with the control group. In the light/dark box test, spinosin exerted an anxiolytic-like effect at 5 mg/kg. In the open-field test, 5 mg/kg spinosin increased the number of central entries. Spinosin did not affect spontaneous activity. The anxiolytic-like effects of spinosin in the elevated plus maze, light/dark box test, and open field test were blocked by the gamma-aminobutyric acid-A (GABA(A)) receptor antagonist flumazenil (3 mg/kg, i.p.) and 5-hydroxytryptamine-1A (5-HT1A) receptor antagonist WAY-100635 (1 mg/kg, i.p.). These results suggest that spinosin exerts anxiolytic-like effects, and its mechanism of action appears to be modulated by GABA(A) and 5-HT1A receptors. (C) 2014 Elsevier Inc. All rights reserved.
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