期刊
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
卷 10, 期 1, 页码 616-621出版社
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jnn.2010.1732
关键词
Dexamethasone; Drying; Granules; Nanoparticles; Nanocapsules; Stability; Wet Granulation
类别
资金
- FAPERGS
- Rede Nanocosmeticos CNPq/MCT-Brazil
- Universal CNPq/MCT
- CNPq/IBSA
- FIPE Jr/UFSM
The industrial development of polymeric nanoparticle suspensions is still limited due to their low physicochemical stability. In this paper, we evaluated the wet granulation process as an alternative method to dry polymeric nanocapsules using dexamethasone as drug model. Nanocapsule suspensions were used as granulating liquid as well as a drug-loaded-nanocarrier in the wet granulation process. Granules were evaluated regarding their drug content, mean particle size, yield, moisture content, flow properties, stability on storage, recovery studies after water redispersion and morphological characteristics (SEM). Granules containing dexamethasone-loaded polymeric nanocapsules presented good drug content (similar to 94%) and were stable for 6 months at room temperature. Morphological analyses showed nanostructures on their surface and the nanoparticles were recovered after redispersing the granules in water. These results suggest that wet granulation can be an interesting alternative to dry drug-loaded nanocapsule suspensions.
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