期刊
PHARMACOLOGY
卷 95, 期 1-2, 页码 42-49出版社
KARGER
DOI: 10.1159/000370314
关键词
Multielectrode array; Cocaine-conditioned place preference; Social interaction-conditioned place preference; Spontaneous activity; Spike frequency; Nucleus accumbens; Septum
资金
- Austrian Science Fund (FWF) graduate program 'Signal Processing in Neurons' [W1206-B18]
- FWF [P26248-B24, P23824-B18]
- Austrian Science Fund (FWF) [P 23824] Funding Source: researchfish
Both cocaine and social interaction place preference conditioning lead to increased neuronal expression of the immediate early gene EGR1 in the nucleus accumbens, a central region of the reward pathway, suggesting that both drug and natural rewards may be processed in similar brain regions. In order to gain novel insights into the intrinsic in vitro electrical activity of the nucleus accumbens and adjacent brain regions and to explore the effects of reward conditioning on network activity, we performed multielectrode array recordings of spontaneous firing in acute brain slices of mice conditioned to either cocaine or social interaction place preference. Cocaine conditioning increased the spike frequency of neurons in the septal nuclei, whereas social interaction conditioning increased the spike frequency in the nucleus accumbens compared to saline control animals. In addition, social interaction conditioning decreased the amount of active neuron clusters in the nucleus accumbens. Our findings suggest that place preference conditioning for both drug and natural rewards may induce persistent changes in neuronal network activity in the nucleus accumbens and the septum that are still preserved in acute slice preparations. (C) 2015 S. Karger AG, Basel
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据