期刊
PHARMACOLOGICAL RESEARCH
卷 99, 期 -, 页码 377-381出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phrs.2015.05.007
关键词
Mitochondria; Calcium; Neurodegeneration; Neurons; Astrocyte; Alzheimer's disease; Parkinson's disease
Functional mitochondria are vital to accomplish their key role in the cell, by maintaining the energy metabolism, buffering of the Ca2+ signal and directing the cell death mechanism. Mitochondrial Ca2+ can stimulate ATP production or trigger the opening of mitochondrial permeability transition pore and activating the cell death cascade. Mitochondrial Ca2+ uptake play a crucial role in neurons by buffering excessive Ca2+ from the cytosol at the time of the transmission of the signal. Changes in the maintenance of mitochondrial Ca2+ may trigger neuronal cell death. Abnormality in mitochondrial Ca2+ handling has been detected in a range of neurodegenerative diseases, and emerging evidence from disease models suggests that mitochondrial Ca2+ may play a role in disease pathogenesis. In this review, we assess how mitochondrial Ca2+ imbalance may be a trigger in common neurodegenerative disease. (C) 2015 Elsevier Ltd. All rights reserved.
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