期刊
PHARMACOLOGICAL RESEARCH
卷 99, 期 -, 页码 382-392出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phrs.2015.04.013
关键词
Mitochondria; Calcium dysregulation; Cell death; Metabolism; Ion channels
资金
- NIH [NS045876, NS081746]
- American Heart Association [12GRNT12060233]
Ion transport across the mitochondrial inner and outer membranes is central to mitochondrial function, including regulation of oxidative phosphorylation and cell death. Although essential for ATP production by mitochondria, recent findings have confirmed that the c-subunit of the ATP synthase also houses a large conductance uncoupling channel, the mitochondrial permeability transition pore (mPTP), the persistent opening of which produces osmotic dysregulation of the inner mitochondrial membrane and cell death. This review will discuss recent advances in understanding the molecular components of mPTP, its regulatory mechanisms and how these contribute directly to its physiological as well as pathological roles. (C) 2015 Elsevier Ltd. All rights reserved.
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