Calumenin and fibulin-1 on tumor metastasis: Implications for pharmacology

Tumor metastasis is a key cause of cancer mortality, and inhibiting migration of cancer cells is one of the major directions of anti-metastatic drug development. Calumenin and fibulin-1 are two extracellular proteins that synergistically inhibit cell migration and tumor metastasis, and could potentially be served as targets for pharmacological research of anti-metastatic drugs. This review briefly introduces the multifunction of these two proteins, and discusses the mechanism of how they regulate cell migration and tumor metastasis. (C) 2015 Elsevier Ltd. All rights reserved.