期刊
JOURNAL OF NANOPARTICLE RESEARCH
卷 15, 期 9, 页码 -出版社
SPRINGER
DOI: 10.1007/s11051-013-1911-z
关键词
Targeted; Prodrug; Photodynamic; pH-triggered release; Carbon nanotube
资金
- National Key Basic Research Program of China [2013CB 834702]
- NSFC [21025415, 21174040]
Herein, we describe a multifunctional anti-cancer prodrug system based on water-dispersible carbon nanotube (CNT); this prodrug system features active targeting, pH-triggered drug release, and photodynamic therapeutic properties. For this prodrug system (with the size of similar to 100-300 nm), an anticancer drug, doxorubicin (DOX), was incorporated onto CNT via a cleavable hydrazone bond; and a targeting ligand (folic acid) was also coupled onto CNT. This prodrug can preferably enter folate receptor (FR)-positive cancer cells and undergo intracellular release of the drug triggered by the reduced pH. The targeted CNT-based prodrug system can cause lower cell viability toward FR-positive cells compared to the non-targeted ones. Moreover, the CNT carrier exhibits photodynamic therapeutic (PDT) action; and the cell viability of FR-positive cancer cells can be further reduced upon light irradiation. The dual effects of pH-triggered drug release and PDT increase the therapeutic efficacy of the DOX-CNT prodrug. This study may offer some useful insights on designing and improving the applicability of CNT for other drug delivery systems.
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