期刊
JOURNAL OF NANOPARTICLE RESEARCH
卷 12, 期 1, 页码 55-60出版社
SPRINGER
DOI: 10.1007/s11051-009-9692-0
关键词
Nanoparticles; Gold; Immune system; Dendritic cells; Cytotoxicity; Cytokine; Nanomedicine; EHS
资金
- European Community [FP6-NMP-CT-2006-032731]
The effect of manufactured gold nanoparticles (NPs) on the immune system was analysed through their ability to perturb the functions of dendritic cells (DCs), a major actor of both innate and acquired immune responses. For this purpose, DCs were produced in culture from mouse bone marrow progenitors. The analysis of the viability of the cells after their incubation in the presence of gold NPs shows that these NPs are not cytotoxics even at high concentration. Furthermore, the phenotype of the DC is unchanged after the addition of NPs, indicating that there is no activation of the DC. However, the analysis of the cells at the intracellular level reveals important amounts of gold NPs amassing in endocytic compartments. Furthermore, the secretion of cytokines is significantly modified after such internalisation indicating a potential perturbation of the immune response.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据