期刊
JOURNAL OF NANOPARTICLE RESEARCH
卷 12, 期 2, 页码 663-673出版社
SPRINGER
DOI: 10.1007/s11051-009-9635-9
关键词
Up-conversion fluorescence; Drug release; Mesoporous silica; Drug delivery; Nanomedicine
资金
- National Basic Research Program of China [2007CB935 502]
- National Natural Science Foundation of China (NSFC) [50702057, 50872131, 00610227]
NaYF4:Yb3+, Er3+ nanoparticles were successfully prepared by a polyol process using diethyleneglycol (DEG) as solvent. These NaYF4:Yb3+, Er3+ nanoparticles can be coated with mesoporous silica using nonionic triblock copolymer EO20PO70 EO20 (P 123) as structure-directing agent and other materials. The composites can load ibuprofen and release the drug in the phosphate buffer solution (PBS). The composites were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), nitrogen absorption/desorption isotherms, fluorescence spectra, and UV/Vis absorption spectra, respectively. The composites have the mesoporous structure. In addition, the composites emit red fluorescence (from Er3+) under 980 nm near infrared laser excitation, which can be used as fluorescent probes in the drug-delivery system.
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