Magnetic Nanoparticle Hyperthermia Using Pluronic-Coated Fe3O4 Nanoparticles: An In Vitro Study

Magnetic nanoparticles are promising materials for hyperthermia treatment. The temperature rise under ac magnetic field, cytotoxicity, and in vitro hyperthermia effect of Fe3O4 nanoparticles coated with Pluronic f-127 were evaluated in this paper. The Pluronic-coated Fe3O4 nanoparticles exhibited no cytotoxic effect on HeLa cells. The optimal magnetic field of Pluronic-coated Fe3O4 nanoparticles was 16 kA/m (200 Oe) at the field strength of 210 kHz. Appropriate temperature rise significantly reduced the viability of HeLa cells and induced apoptosis.