期刊
JOURNAL OF NANOMATERIALS
卷 2011, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2011/830436
关键词
-
资金
- Pittsburgh Supercomputing Center [MCB080010P]
- Commonwealth of Pennsylvania
Understanding the interaction between a carbon nanotube and biological macromolecules such as lipid bilayers is important for the design and development of nanovectors for gene and drug delivery. The forces of penetration and the free energies of rupture of lipid bilayers during nanotube penetration were studied using nonequilibrium, all-atom molecular dynamics simulations for pure POPC and POPC/cholesterol bilayers. The presence of cholesterol did not alter the magnitude of the rupture force and minimally increased the estimated free energy of rupture. However, the ability of the nanotube to disrupt the membrane leading to membrane poration increased with increasing cholesterol content.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据