期刊
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY
卷 30, 期 5-6, 页码 171-185出版社
SPRINGER
DOI: 10.1007/s10974-009-9189-6
关键词
Z-line; Z-band; Muscle proteins; Actin; Alpha-actinin; Electron microscopy
类别
资金
- British Heart Foundation [PG/06/010]
The Z-disc, appearing as a fine dense line forming sarcomere boundaries in striated muscles, when studied in detail reveals crosslinked filament arrays that transmit tension and house myriads of proteins with diverse functions. At the Z-disc the barbed ends of the antiparallel actin filaments from adjoining sarcomeres interdigitate and are crosslinked primarily by layers of alpha-actinin. The Z-disc is therefore the site of polarity reversal of the actin filaments, as needed to interact with the bipolar myosin filaments in successive sarcomeres. The layers of alpha-actinin determine the Z-disc width: fast fibres have narrow (similar to 30-50 nm) Z-discs and slow and cardiac fibres have wide (similar to not congruent to 100 nm) Z-discs. Comprehensive reviews on the roles of the numerous proteins located at the Z-disc in signalling and disease have been published; the aim here is different, namely to review the advances in structural aspects of the Z-disc.
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