期刊
JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM
卷 911, 期 1-3, 页码 92-97出版社
ELSEVIER
DOI: 10.1016/j.theochem.2009.07.003
关键词
Potential energy scan; Hydrogen bond; N-alpha-substituted hydrazino acetamides; Hydrazinoturn
资金
- Isfahan University of Technology (IUT) [87/500/9143]
We studied a series of model primary amides in gas phase at the DFT (B3LYP) and HF at 6-31+G/6-31+G** levels of theory in order to shed light on their conformation, structure, and intramolecular hydrogen bonding network. A potential energy scan was performed by rotating around the appropriate bond for each molecule studied in this paper. In this manner, it was possible to show that the amidic group of these model compounds acts as H-bond donor and interacts with two different H-bond acceptors which stabilizes a C-8 pseudocycle. the so called hydrazinoturn. This study was addressed theoretically in order to understand the conformation adopted by hydrazino, acetamides as model compounds for aZa-beta(3)-peptides. We thus investigated the conformational analysis of hydrazinoturns computationally and showed that these systems represent a very stabilizing folding driving force, provided that the neighboring molecular functional groups do not imply other competing hydrogen bonding patterns. (C) 2009 Elsevier B.V. All rights reserved.
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