期刊
JOURNAL OF MOLECULAR STRUCTURE
卷 1173, 期 -, 页码 885-893出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.molstruc.2018.07.050
关键词
Dispiroferrocenylphosphazenes; Spectroscopy; Chiral phosphazenes; Antimicrobial activity; Crystal structure
资金
- Scientific and Technical Research Council of Turkey [216Z182]
- Turkish Academy of Sciences (TUBA)
- Hacettepe University Scientific Research Project Unit [013 D04 602 004]
The cis- (5 and 6) and trans-dispiroferrocenylphosphazenes (7 and 8) containing ferrocenyl pendant arms were synthesized from the reactions of hexachlorocyclotriphosphazene, N3P3Cl6, with two equimolar amounts of the sodium salts of the ligands; [2-(N-ferrocenylmethylamino)-1-ethanoxide (1) and 3-(N-ferrocenylmethylamino)-1-propanoxide (2)]. The monospiroferrocenylcyclotriphosphazenes (3 and 4) were also isolated from the reaction mixtures as by-products. The characterizations of the new compounds (5-8) were elucidated using MS, FTIR and H-1, C-13 and P-31 NMR techniques. The molecular structure of 6 was established by X-ray crystallography. As expected, compounds 5, 6, 7 and 8 have two stereogenic P-atoms. The compounds 5 and 6 are likely to be in cis (meso) forms, whereas the compounds 7 and 8 are in trans (racemic) forms. Besides, the antimicrobial activities of the cyclotriphosphazenes against G(+) and G(-) bacteria and fungi were evaluated. The interactions of the compounds with pBR322 plasmid DNA were also investigated. (C) 2018 Elsevier B.V. All rights reserved.
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