Acid-Base and Antioxidant Properties of Complexes of Phytic Acid-Xymedone in Solution

IR, UV, H-1, and C-13 NMR spectroscopic studies and potentiometric titration showed that the interaction of myoinositol hexakisphosphate (InsP(6)H(12)) and 1-(b-hydroxyethyl)-4,6-dimethyl-1,2-dihydro-2-hydroxypyrimidine (xymedone) in aqueous solution occurs via a proton transfer stage to form ionic and H-bonded complexes. In vitro study results using human plasma demonstrated synergism in antioxidant effects and activation of superoxide dismutase by phytic acid and xymedone complexed to form xymedone phytate.