期刊
PHARMACEUTICAL BIOLOGY
卷 54, 期 1, 页码 168-173出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/13880209.2015.1028077
关键词
Biological activity; Clinopodium gilliesii; Lippia integrifolia; Lippia turbinata; piperitenone oxide
资金
- Universidad Nacional de Chilecito [FyCT 2012]
Context: The use of many traditional medicinal plants is often hampered by the absence of a proper biochemical characterization, which is essential to identify the bioactive compounds present in it. The essential oils (EOs) of three native species from the La Rioja province were analyzed: Lippia turbinata Griseb and Lippia integrifolia (Griseb.) Hieron (Verbenaceae), and Clinopodium gilliesii (Benth.) Kuntze (Lamiaceae).Objective: The aim of this study was to evaluate their EOs antioxidant activity (AA) and their chemical composition.Materials and methods: EOs were analyzed by gas chromatography-mass spectrometry (GC-MS). To enhance the aqueous solubilization of the EOs, EO-water emulsions were prepared (concentration range of 0.1-6mgmL(-1)). AA was determined using ABTS, DPPH, and peroxyl radical scavenging assays, as well as by the -carotene bleaching test.Results: Piperitenone oxide was a major constituent in L. turbinata, pulegone and piperitenone oxide in C. gilliesii, and -caryophyllene in L. integrifolia. Lippia turbinata EO was the most active ABTS and DPPH radical scavenger (SC50 values of 0.400.14 and 0.74 +/- 0.08mgmL(-1), respectively). Clinopodium gilliesii EO exhibited the highest hydrogen peroxide scavenging activity (SC25 value=1.52 +/- 0.27mgmL(-1)). In the -carotene assay, L. turbinata EO was more effective at inhibiting lipid peroxidation than the other two oils (IC25 value=0.15 +/- 0.04mgmL(-1)).Conclusion: Our results suggest that the AA observed can be justified by the presence of oxygenated monoterpenes, mainly piperitenone oxide. Finally, L. turbinata EO might be used as a safe natural antioxidant and food preservative in the food and cosmetic industries.
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