期刊
JOURNAL OF MOLECULAR RECOGNITION
卷 24, 期 6, 页码 915-929出版社
WILEY
DOI: 10.1002/jmr.1150
关键词
molecular imprinting; self-assembled monolayers; surface imprinting; molecular recognition
A comprehensive report on molecularly imprinted monolayers (MIMs) is presented, but does not include bulk-polymer thin film coatings on surfaces, inorganic surface imprinting, polymer grafting and layer-by-layer methods. Due to difficulties in imprinting large molecules and obtaining fast binding responses with traditional network polymer materials, MIMs have been developed with the aim of enhancing mass-transfer of analytes in imprinted materials. Three approaches to MIM fabrication have been developed with respect to the formation of the pre-organized template-matrix complex. In the first approach, the molecular binding sites are formed in a monolayer on a glass or gold surface. The second approach uses a template-macromolecule complex to form binding sites in the solution phase that are immobilized onto a surface; and the third approach transfers an imprinted Langmuir film onto a gold surface. Mass transfer in these MIMs inmost cases is on the order of minutes, and both small and large molecules (proteins) have been imprinted. Copyright (C) 2011 John Wiley & Sons, Ltd.
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