期刊
JOURNAL OF MOLECULAR NEUROSCIENCE
卷 47, 期 3, 页码 485-494出版社
HUMANA PRESS INC
DOI: 10.1007/s12031-012-9709-5
关键词
Spy1; Glioma; Prognosis; Proliferation
资金
- National Basic Research Program of China (973 Program) [2011CB910604, 2012BC822104]
- National Natural Science Foundation of China [31070723, 81070275, 81172879]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- College and University Natural Scientific Research Programme of Jiangsu Province [11KJA310002]
Spy1, a member of the Speedy/RINGO family, is a novel activator of cyclin-dependent kinases known to mediate cell cycle progression and cell survival in response to DNA damage. This study focused on the role of Spy1 in glioma oncogenesis. Immunohistochemistry and western blot analysis were performed to examine the expression of Spy1 in human glioma tissues and cell lines. Spy1 was frequently overexpressed in tumor tissues and cultured cells. Our data suggested that Spy1 expression positively correlated with the malignancy of gliomas. Altered expression of Spy1 led to changes in cell cycle processes, cyclin-dependent kinase 2 activity, and p27kip1 protein stabilization, ultimately disrupting cell growth rate. More importantly, high expression of Spy1 was associated with poor prognosis in patients with glioma, suggesting that Spy1 may be a novel independent prognostic predictor of survival for glioma patients. Collectively, this is the first report that Spy1 may play an essential role in the growth processes of human glioma.
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