相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Research Advances in Amyotrophic Lateral Sclerosis, 2009 to 2010
Rebecca Traub et al.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS (2011)
TDP-43 regulates its mRNA levels through a negative feedback loop
Youhna M. Ayala et al.
EMBO JOURNAL (2011)
TDP-43 neurotoxicity and protein aggregation modulated by heat shock factor and insulin/IGF-1 signaling
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HUMAN MOLECULAR GENETICS (2011)
TAR DNA-binding protein 43 (TDP-43) regulates stress granule dynamics via differential regulation of G3BP and TIA-1
Karli K. McDonald et al.
HUMAN MOLECULAR GENETICS (2011)
Identification of Neuronal RNA Targets of TDP-43-containing Ribonucleoprotein Complexes
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JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
A Seeding Reaction Recapitulates Intracellular Formation of Sarkosyl-insoluble Transactivation Response Element (TAR) DNA-binding Protein-43 Inclusions
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JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
A Two-hit Hypothesis for Inclusion Formation by Carboxyl-terminal Fragments of TDP-43 Protein Linked to RNA Depletion and Impaired Microtubule-dependent Transport
G. Scott Pesiridis et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice
Lionel M. Igaz et al.
JOURNAL OF CLINICAL INVESTIGATION (2011)
Regulation of TDP-43 aggregation by phosphorylation andp62/SQSTM1
Owen A. Brady et al.
JOURNAL OF NEUROCHEMISTRY (2011)
TDP-43 Is Directed to Stress Granules by Sorbitol, a Novel Physiological Osmotic and Oxidative Stressor
Colleen M. Dewey et al.
MOLECULAR AND CELLULAR BIOLOGY (2011)
RNA targets of TDP-43 identified by UV-CLIP are deregulated in ALS
Shangxi Xiao et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2011)
Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43
Magdalini Polymenidou et al.
NATURE NEUROSCIENCE (2011)
Characterizing the RNA targets and position-dependent splicing regulation by TDP-43
James R. Tollervey et al.
NATURE NEUROSCIENCE (2011)
Both cytoplasmic and nuclear accumulations of the protein are neurotoxic in Drosophila models of TDP-43 proteinopathies
Laetitia Miguel et al.
NEUROBIOLOGY OF DISEASE (2011)
TDP-43-Based Animal Models of Neurodegeneration: New Insights into ALS Pathology and Pathophysiology
Iga Wegorzewska et al.
NEURODEGENERATIVE DISEASES (2011)
TDP-43 Regulates Drosophila Neuromuscular Junctions Growth by Modulating Futsch/MAP1B Levels and Synaptic Microtubules Organization
Vinay K. Godena et al.
PLOS ONE (2011)
Implications of the prion-related Q/N domains in TDP-43 and FUS
Maria Udan et al.
PRION (2011)
Pathogenic TARDBP Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia: Disease-Associated Pathways
Sami J. Barmada et al.
REVIEWS IN THE NEUROSCIENCES (2011)
Protein coding of neurodegenerative dementias: the neuropathological basis of biomarker diagnostics
Gabor G. Kovacs et al.
ACTA NEUROPATHOLOGICA (2010)
Loss of murine TDP-43 disrupts motor function and plays an essential role in embryogenesis
Brian C. Kraemer et al.
ACTA NEUROPATHOLOGICA (2010)
Molecular Pathways of Frontotemporal Lobar Degeneration
Kristel Sleegers et al.
ANNUAL REVIEW OF NEUROSCIENCE, VOL 33 (2010)
Expression proteomics of UPF1 knockdown in HeLa cells reveals autoregulation of hnRNP A2/B1 mediated by alternative splicing resulting in nonsense-mediated mRNA decay
Nicholas J. McGlincy et al.
BMC GENOMICS (2010)
Aberrant RNA processing events in neurological disorders
Karen Anthony et al.
BRAIN RESEARCH (2010)
Protein Aggregation and Defective RNA Metabolism as Mechanisms for Motor Neuron Damage
N. Ticozzi et al.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2010)
Biomarkers in frontotemporal lobar degeneration
Murray Grossman
CURRENT OPINION IN NEUROLOGY (2010)
Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6
Fabienne C. Fiesel et al.
EMBO JOURNAL (2010)
Neurons don't appreciate FUSsing in the cytoplasm
Emanuele Buratti et al.
EMBO JOURNAL (2010)
ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import
Dorothee Dormann et al.
EMBO JOURNAL (2010)
Sporadic ALS has compartment-specific aberrant exon splicing and altered cell-matrix adhesion biology
Stuart J. Rabin et al.
HUMAN MOLECULAR GENETICS (2010)
Gain and loss of function of ALS-related mutations of TARDBP (TDP-43) cause motor deficits in vivo
Edor Kabashi et al.
HUMAN MOLECULAR GENETICS (2010)
Neurotoxic effects of TDP-43 overexpression in C-elegans
Peter E. A. Ash et al.
HUMAN MOLECULAR GENETICS (2010)
TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration
Clotilde Lagier-Tourenne et al.
HUMAN MOLECULAR GENETICS (2010)
TDP-43: A DNA and RNA binding protein with roles in neurodegenerative diseases
Sadaf T. Warraich et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2010)
Characterization of Alternative Isoforms and Inclusion Body of the TAR DNA-binding Protein-43
Yoshinori Nishimoto et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Interaction with Polyglutamine Aggregates Reveals a Q/N-rich Domain in TDP-43
Rodrigo A. Fuentealba et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Elevated expression of TDP-43 in the forebrain of mice is sufficient to cause neurological and pathological phenotypes mimicking FTLD-U
Kuen-Jer Tsai et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2010)
Phosphorylation Promotes Neurotoxicity in a Caenorhabditis elegans Model of TDP-43 Proteinopathy
Nicole F. Liachko et al.
JOURNAL OF NEUROSCIENCE (2010)
Wild-Type Human TDP-43 Expression Causes TDP-43 Phosphorylation, Mitochondrial Aggregation, Motor Deficits, and Early Mortality in Transgenic Mice
Ya-Fei Xu et al.
JOURNAL OF NEUROSCIENCE (2010)
Global Analysis of TDP-43 Interacting Proteins Reveals Strong Association with RNA Splicing and Translation Machinery
Brian D. Freibaum et al.
JOURNAL OF PROTEOME RESEARCH (2010)
Induction of Amyloid Fibrils by the C-Terminal Fragments of TDP-43 in Amyotrophic Lateral Sclerosis
Allan K. -H. Chen et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)
The evidence for altered RNA metabolism in amyotrophic lateral sclerosis (ALS)
Michael J. Strong
JOURNAL OF THE NEUROLOGICAL SCIENCES (2010)
TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia
Ian R. A. Mackenzie et al.
LANCET NEUROLOGY (2010)
Phosphorylation regulates proteasomal-mediated degradation and solubility of TAR DNA binding protein-43 C-terminal fragments
Yong-Jie Zhang et al.
MOLECULAR NEURODEGENERATION (2010)
Expansive Gene Transfer in the Rat CNS Rapidly Produces Amyotrophic Lateral Sclerosis Relevant Sequelae When TDP-43 is Overexpressed
David B. Wang et al.
MOLECULAR THERAPY (2010)
TAR DNA-binding protein 43 in neurodegenerative disease
Alice S. Chen-Plotkin et al.
NATURE REVIEWS NEUROLOGY (2010)
Progressive motor weakness in transgenic mice expressing human TDP-43
Nancy R. Stallings et al.
NEUROBIOLOGY OF DISEASE (2010)
RNA processing pathways in amyotrophic lateral sclerosis
Marka van Blitterswijk et al.
NEUROGENETICS (2010)
Phosphorylated and cleaved TDP-43 in ALS, FTLD and other neurodegenerative disorders and in cellular models of TDP-43 proteinopathy
Tetsuaki Arai et al.
NEUROPATHOLOGY (2010)
Review: Recent progress in frontotemporal lobar degeneration
S. M. Pickering-Brown
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2010)
Review: Transactive response DNA-binding protein 43 (TDP-43): mechanisms of neurodegeneration
T. F. Gendron et al.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2010)
TDP-43-Mediated Neuron Loss In Vivo Requires RNA-Binding Activity
Aaron Voigt et al.
PLOS ONE (2010)
The C-Terminal TDP-43 Fragments Have a High Aggregation Propensity and Harm Neurons by a Dominant-Negative Mechanism
Chunxing Yang et al.
PLOS ONE (2010)
Tar DNA Binding Protein-43 (TDP-43) Associates with Stress Granules: Analysis of Cultured Cells and Pathological Brain Tissue
Liqun Liu-Yesucevitz et al.
PLOS ONE (2010)
ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS
Shuo-Chien Ling et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
A Drosophila model for TDP-43 proteinopathy
Yan Li et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism
Po-Min Chiang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Altered distributions of Gemini of coiled bodies and mitochondria in motor neurons of TDP-43 transgenic mice
Xiu Shan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration
Hans Wils et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Transgenic Rat Model of Neurodegeneration Caused by Mutation in the TDP Gene
Hongxia Zhou et al.
PLOS GENETICS (2010)
TARDBP 3'-UTR variant in autopsy-confirmed frontotemporal lobar degeneration with TDP-43 proteinopathy
Michael A. Gitcho et al.
ACTA NEUROPATHOLOGICA (2009)
Depletion of TDP-43 affects Drosophila motoneurons terminal synapsis and locomotive behavior
Fabian Feiguin et al.
FEBS LETTERS (2009)
Truncation and pathogenic mutations facilitate the formation of intracellular aggregates of TDP-43
Takashi Nonaka et al.
HUMAN MOLECULAR GENETICS (2009)
Mutations in TDP-43 link glycine-rich domain functions to amyotrophic lateral sclerosis
G. Scott Pesiridis et al.
HUMAN MOLECULAR GENETICS (2009)
Molecular Neuropathology of TDP-43 Proteinopathies
Manuela Neumann
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2009)
Expression of TDP-43 C-terminal Fragments in Vitro Recapitulates Pathological Features of TDP-43 Proteinopathies
Lionel M. Igaz et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
TDP-43 Is Intrinsically Aggregation-prone, and Amyotrophic Lateral Sclerosis-linked Mutations Accelerate Aggregation and Increase Toxicity
Brian S. Johnson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Rapamycin Rescues TDP-43 Mislocalization and the Associated Low Molecular Mass Neurofilament Instability
Antonella Caccamo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Recent advances in our understanding of neurodegeneration
Kurt A. Jellinger
JOURNAL OF NEURAL TRANSMISSION (2009)
Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin
Dorothee Dormann et al.
JOURNAL OF NEUROCHEMISTRY (2009)
TDP-43 is recruited to stress granules in conditions of oxidative insult
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JOURNAL OF NEUROCHEMISTRY (2009)
Amyotrophic lateral sclerosis, frontotemporal dementia and beyond: the TDP-43 diseases
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Cross-Seeding Fibrillation of Q/N-Rich Proteins Offers New Pathomechanism of Polyglutamine Diseases
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Auto- and Cross-Regulation of the hnRNP L Proteins by Alternative Splicing
Oliver Rossbach et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
Nonsense-mediated mRNA decay (NMD) mechanisms
Saverio Brogna et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2009)
TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration
Iga Wegorzewska et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity
Yong-Jie Zhang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Frontotemporal dementia and amyotrophic lateral sclerosis-associated disease protein TDP-43 promotes dendritic branching
Yubing Lu et al.
MOLECULAR BRAIN (2009)
ALS and FTLD: two faces of TDP-43 proteinopathy
R. M. Liscic et al.
EUROPEAN JOURNAL OF NEUROLOGY (2008)
Variations in the progranulin gene affect global gene expression in frontotemporal lobar degeneration
Alice S. Chen-Plotkin et al.
HUMAN MOLECULAR GENETICS (2008)
Structural determinants of the cellular localization and shuttling of TDP-43
Youhna M. Ayala et al.
JOURNAL OF CELL SCIENCE (2008)
TDP-43 accumulation in inclusion body myopathy muscle suggests a common pathogenic mechanism with frontotemporal dementia
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JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2008)
TDP-43 is a culprit in human neurodegeneration, and not just an innocent bystander
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MAMMALIAN GENOME (2008)
TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis
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NATURE GENETICS (2008)
TDP-43 regulates retinoblastoma protein phosphorylation through the repression of cyclin-dependent kinase 6 expression
Youhna M. Ayala et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
A yeast TDP-43 proteinopathy model: Exploring the molecular determinants of TDR-43 aggregation and cellular toxicity
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Stress granules: The Tao of RNA triage
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TRENDS IN BIOCHEMICAL SCIENCES (2008)
The exosome: a multipurpose RNA-decay machine
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TRENDS IN BIOCHEMICAL SCIENCES (2008)
Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43
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JOURNAL OF NEUROSCIENCE (2007)
Gene expression analysis of frontotemporal lobar degeneration of the motor neuron disease type with ubiquitinated inclusions
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ACTA NEUROPATHOLOGICA (2007)
TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)
Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
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SCIENCE (2006)
Autoregulation of polypyrimidine tract binding protein by alternative splicing leading to nonsense-mediated decay
MC Wollerton et al.
MOLECULAR CELL (2004)
TIA-1 and TIAR activate splicing of alternative exons with weak 5′ splice sites followed by a U-rich stretch on their own pre-mRNAs
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