The Triplet Puzzle of Homologies in Receptor Heteromers Exists Also in Other Types of Protein-Protein Interactions

Based on our theory, we point out main triplets of amino acid residues in the GABAB1 receptor, found in the central and peripheral nervous system, which seem to be critical for both receptor heterodimerization and chemokine binding. The obtained results suggest that these triplets may guide-and-clasp protein-protein interactions playing a role, e.g., in neuroinflammation disorders.