期刊
JOURNAL OF MOLECULAR NEUROSCIENCE
卷 39, 期 1-2, 页码 99-103出版社
HUMANA PRESS INC
DOI: 10.1007/s12031-009-9186-7
关键词
Galectin-3; MAC-2; Phagocytosis; Wallerian degeneration; Neurodegenetation; Myelin
资金
- Israel Science Foundation [11/06]
Microglia are a self-sustained population of immune/myeloid cells present throughout the central nervous system (CNS). Microglia are in a resting state in the normal adult CNS. They turn active in injury and disease (e.g., trauma, neurodegeneration, and infection). Activated microglia can be beneficial as well as detrimental/neurotoxic. The innate-immune function of phagocytosis of tissue debris, neurotoxic factor, and pathogens is a beneficial function of microglia. The current manuscript reviews the role of Galectin-3 (known also as MAC-2; Galectin-3/MAC-2) in the activation of the phagocytosis of degenerated myelin that is mediated by complement receptor-3 (known also as MAC-1; CD11b/CD18; alpha M beta 2 integrin) and SRA (scavenger receptor-AI/II). Observations suggest that Galectin-3/MAC-2 may act as a molecular switch that activates phagocytosis by up-regulating and prolonging KRas-GTP-dependent PI3K (phosphatidylinositol 3-kinase) activity. A similar mechanism may regulate the phagocytosis of other tissue debris, neurotoxic factors and pathogens in neurodegenerative and infectious diseases.
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