期刊
JOURNAL OF MOLECULAR NEUROSCIENCE
卷 39, 期 1-2, 页码 22-26出版社
HUMANA PRESS INC
DOI: 10.1007/s12031-008-9168-1
关键词
Neprilysin; Estrogen; Yeast report gene system; Alzheimer's disease; beta-galactosidase
资金
- Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry of China [2004527]
- Hubei Province Natural Science Foundation of China [2006ABA219]
- National Natural Science Foundation of China [30670647]
Our previous data showed that neprilysin (NEP), a zinc metalloendopeptidase, which can degrade amyloid-beta peptide (A beta) whose central nerve system accumulation is the primary cause of Alzheimer's disease (AD), responds to estrogen in the brain. Recently, it has been shown that the transcription of the neprilysin gene can be up regulated by progesterone, androgens, and glucocorticoids through two androgen response elements within the NEP gene-an androgen response region (ARR) and an androgen response element (ARE). Through a yeast report gene system, we now find that the ARR but not the ARE respond to estrogen. However, androgen could efficiently enhance the expression of the report gene mainly through ARE. Our results indicate that the decrease of NEP, caused by the decline of estrogen or androgen with aging, may be an important factor leading to A beta accumulation and AD.
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